In progress

• Partnership for the Assessment of Risk from Chemicals (PARC) (01.05.2022–30.04.2029); Principal Investigator: Uko Maran; University of Tartu, Faculty of Science and Technology, Institute of Chemistry; Financier: European Commission; Ministry of Social Affairs; Ministry of Climate.
• Data driven modelling of physical-chemical-biological properties of complex molecular environments and functional materials (01.01.2022–31.12.2026); Principal Investigator: Uko Maran; University of Tartu, Faculty of Science and Technology, Institute of Chemistry; Financier: Estonian Research Council.

Completed

Partition properties of drugs substances (08.05.2023–31.12.2025); Principal Investigator: Uko Maran; University of Tartu, Faculty of Science and Technology, Institute of Chemistry; Financier: Adamed Pharma SA.

• Therapeutic ligands for RNA-epigenetic enzyme targets. High-throughput virtual screening and measurement of neuroprotective activity of the RNA demethylation enzymes AlkBH5 and FTO (16.01.2017–31.12.2024); Principal Investigator: Mati Karelson; University of Tartu, Faculty of Science and Technology, Institute of Chemistry; Financier: Chemestmed Ltd.
• Novel RNA m6A methyltransferase activators for Parkinson’s disease (01.12.2021–30.11.2024); Principal Investigator: Mati Karelson; University of Tartu, Faculty of Science and Technology, Institute of Chemistry ; Financier: The Cure Parkinson´s Trust.
• Bioactive chemical space for cervical cancer: cheminformatics analysis of chemical structure patterns, machine learning modelling of diverse chemical space and discovery of new bioactive structures (01.10.2021–30.09.2023); Principal Investigator: Selma Zukić; University of Tartu, Faculty of Science and Technology, Institute of Chemistry ; Financier: Estonian Research Council.
• Drug solubility in human intestinal fluids: multi-objective analysis and modelling (1.10.2019-30.09.2022); Principal Investigator: Uko Maran; University of Tartu, Faculty of Science and Technology, Institute of Chemistry; Financier (CELSA network): University of Tartu, KU Leuven (Belgium)
• Compatibility of QsarDB prediction services applicability domain representation with QSAR Toolbox platform (01.11.2018–28.02.2019); Principal Investigator: Uko Maran; University of Tartu, Faculty of Science and Technology, Institute of Chemistry; Financier: European Chemicals Agency.
• Support and development framework for OECD (Q)SAR Toolbox project (01.05.2017–30.04.2020); Principal Investigator: Uko Maran; University of Tartu, Faculty of Science and Technology, Institute of Chemistry; Financier: Organisation for Economic Co-operation and Development (OECD).
• Therapeutic ligands for RNA-epigenetic enzyme targets (16.01.2017–31.12.2021); Principal Investigator: Mati Karelson; University of Tartu, Faculty of Science and Technology, Institute of Chemistry; Financier: Chemestmed Ltd.
• Descriptive and predictive modelling and design in elucidating chemico-biological interactions and assessing chemical safety (01.01.2015–31.12.2020); Principal Investigator: Uko Maran; University of Tartu, Faculty of Science and Technology, Institute of Chemistry; Financier: Estonian Research Council.
• Structure-property relationships of peptides (01.01.2015–31.12.2018); Principal Investigator: Mati Karelson; University of Tartu, Faculty of Science and Technology, Institute of Chemistry; Financier: Estonian Research Council.
• In silico modeling of DNA polymerases having high replicative and strand displacement capability (01.01.2015–31.12.2016); Principal Investigator: Indrek Tulp; University of Tartu, Faculty of Science and Technology, Institute of Chemistry; Financier: Estonian Research Council.
• Design and synthesis of N-alkylsulphonamides (01.04.2014–31.08.2014); Principal Investigator: Mati Karelson; University of Tartu; Financier: Genecode Ltd..
• Chemlnformatic platform for organization and sharing of predective models for knowledge Discovery (01.04.2013–30.09.2015); Principal Investigator: Uko Maran; University of Tartu, Faculty of Science and Technology (old), Institute of Chemistry; Financier: Archimedes Foundation.
• Small-scale research infrastructure modernization for the project SF0140031Bs09 (01.01.2013–31.12.2014); Principal Investigator: Uko Maran; University of Tartu, Faculty of Science and Technology (old), Institute of Chemistry; Financier: Ministry of Education and Research.
• Development of Trk antagonists as drug canditates for the treatment of neuropathic pain (01.09.2012–31.08.2015); Principal Investigator: Mati Karelson; University of Tartu; Financier: Archimedes Foundation.
• Small-scale research infrastructure modernization for the project SF0140031Bs09 (01.01.2011–31.12.2012); Principal Investigator: Uko Maran; University of Tartu, Faculty of Science and Technology (old), Institute of Chemistry; Financier: Ministry of Education and Research.
• Neublastiini agonistide disain (01.04.2011–31.05.2011); Principal Investigator: Mati Karelson; University of Tartu; Financier: Chemedest Ltd..
• Application of computational chemistry in the study of complex molecular systems of large biomedical and environmental importance (01.01.2010–31.12.2014); Principal Investigator: Uko Maran; University of Tartu, Faculty of Science and Technology (old), Institute of Chemistry, Tartu University; Financier: Ministry of Education and Research.
• Synthesis of artificial nucleases and their conjugation with oligonucleotides (Part of the project "Optimization of structure of the gene technology based antiviral drug candidates (OLIGO-MOD) (01.10.2010–30.11.2010); Principal Investigator: Mati Karelson; University of Tartu; Financier: Baltic Technology Development Ltd..
• Environmental risks of nanostructured materials (01.04.2010–31.12.2010); Principal Investigator: Jaan Leis; University of Tartu; Financier: Port of Tallinn.
• Merekaubanduses käideldavate ainete toksilisuse andmebaas (struktuurid ja omadused) (01.06.2009–30.11.2009); Principal Investigator: Mati Karelson; University of Tartu ; Financier: Port of Tallinn.
• Synthesis of artificial nucleases and conjugating these with oligonucleotides" (Part of the project “Optimization of the structure of gene technology based antiviral drug candidates (OLOGO-MOD) (01.06.2009–30.11.2009); Principal Investigator: Mati Karelson; University of Tartu; Financier: Baltic Technology Development Ltd..
• Magnetiliselt aktiivsete keemiliste ühendite süntees (01.12.2009–15.01.2010); Principal Investigator: Mati Karelson; University of Tartu ; Financier: Estiko-Plastar AS.
• Methods for the validation and definition of applicability domain of quantitative structure activity relationships, their development and application (01.01.2008–31.12.2011); Principal Investigator: Uko Maran; University of Tartu, Faculty of Science and Technology (old), Institute of Chemistry; Financier: Estonian Science Foundation.
• More effective application of structure-property relationship methods for complex molecular modeling and design problems. (01.01.2008–31.12.2010); Principal Investigator: Sulev Sild; University of Tartu, Faculty of Science and Technology (old), Institute of Chemistry; Financier: Estonian Science Foundation.
• Synthesis of magnetically active chemical compounds (01.04.2008–31.01.2009); Principal Investigator: Mati Karelson; University of Tartu; Financier: AS Estiko-Plastar.
• Synthesis of quinolinamides and -amines (01.02.2008–30.11.2008); Principal Investigator: Mati Karelson; University of Tartu ; Financier: Baltic Technology Development Ltd..
• Biotehnoloogiliste ja makromolekulaarsete süsteemide molekulaardisain (01.01.2007–31.12.2008); Principal Investigator: Uko Maran; University of Tartu, Faculty of Physics and Chemistry, Institute of Chemical Physics; Financier: Estonian Science Foundation.
• Sustainable high energy density materials (01.05.2007–31.01.2008); Principal Investigator: Mati Karelson; University of Tartu; Financier: Port of Tallinn.
• Synthesis of modified oligonucleotides and their lanthanide complexes (01.01.2007–31.12.2007); Principal Investigator: Mati Karelson; University of Tartu; Financier: Baltic Technology Development Ltd..
• Synthesis of quinoline derivatives (01.06.2007–30.11.2007); Principal Investigator: Mati Karelson; University of Tartu ; Financier: Baltic Technology Development Ltd..
• Improving the international competitiveness of education and research development in modern molecular technology (01.07.2006–30.06.2008); Principal Investigator: Uko Maran; University of Tartu; Financier: Foundation Innove.
• Grid services based environments to enable innovative research (01.07.2006–01.04.2009); Principal Investigator: Uko Maran; University of Tartu; Financier: European Commission.
• Synthesis and physical properties of indigo-type polymers (15.12.2006–31.03.2007); Principal Investigator: Mati Karelson; University of Tartu; Financier: Raidenil OÜ.
• Drug Design for Cardiovascular Diseases: Integration of in Silico and in Vitro Analysis (01.12.2005–01.06.2009); Principal Investigator: Uko Maran; University of Tartu; Financier: European Commission.
• Database on the structure and properties of marine toxic chemicals (15.01.2005–15.07.2005); Principal Investigator: Mati Karelson; University of Tartu; Financier: Port of Tallinn.
• Molecular design of biotechnological and macromolecular systems (01.01.2004–31.12.2008); Principal Investigator: Uko Maran; University of Tartu, Faculty of Physics and Chemistry; Financier: Ministry of Education and Research.
• The classification of toxic chemicals and estimation of their toxcicty based on chemical structure (01.01.2004–31.12.2007); Principal Investigator: Uko Maran; University of Tartu, Faculty of Physics and Chemistry ; Financier: Estonian Science Foundation.
• Understanding NANO-materials from the QUANTum perspective (01.04.2004–31.03.2007); Principal Investigator: Mati Karelson; University of Tartu; Financier: European Commission.
• QSPR/QSAR Approaches for Complex and Large Data Sets (01.01.2003–31.12.2006); Principal Investigator: Sulev Sild; University of Tartu, Faculty of Physics and Chemistry; Financier: Estonian Science Foundation.